Immune escape from HIV-specific antibody-dependent cellular cytotoxicity (ADCC) pressure

AW Chung; G Isitman; M Navis; M Kramski; RJ Center; SJ Kent; I Stratov

Journal article

Immune escape from HIV-specific antibody-dependent cellular cytotoxicity (ADCC) pressure

AW Chung, G Isitman, M Navis, M Kramski, RJ Center, SJ Kent, I Stratov

Proceedings of the National Academy of Sciences of the United States of America | Published : 2011

DOI: 10.1073/pnas.1016048108

Abstract

Effective immunity to HIV is poorly understood. In particular, a role for antibody-dependent cellular cytotoxicity (ADCC) in controlling HIV is controversial. We hypothesized that significant pressure from HIV-specific ADCC would result in immune-escape variants. A series of ADCC epitopes in HIV-infected subjects to specific consensus strain HIV peptides were mapped using a flow cytometric assay for natural killer cell activation. We then compared the ADCC responses to the same peptide epitope derived from the concurrent HIV sequence(s) expressed in circulating virus. In 9 of 13 epitopes studied, ADCC antibodies were unable to recognize the concurrent HIV sequence. Our studies suggest ADCC r..

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University of Melbourne Researchers

Amy Chung Author

Stephen Kent Author

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Grants

Awarded by National Institute of Allergy and Infectious Diseases

Funding Acknowledgements

We are grateful to A. Brooks, L. Wren, C. Birch, D. Chibo, J. Silvers, and the subjects studied for assistance with these studies. We thank B. Korber for providing the unique Env sequences. This work was supported by National Health and Medical Research Council Grant 510448, Australian Research Council Grant LP0991498, and National Institutes of Health Grant R21AI081541, and by the Australian Centre for HIV and Hepatitis Virology Research, the Royal Australasian College of Physicians, and the Ramaciotti Foundation.